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Dynamic flexibility in the Escherichia coli genome
Author(s) -
Tsai Lu,
Sun Zhirong
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02978-7
Subject(s) - escherichia coli , genome , flexibility (engineering) , computational biology , coding region , genetics , coding (social sciences) , biology , twist , computer science , mathematics , gene , statistics , geometry
Empirical rules based on tetranucleotide parameters were presented to predict the structural parameters twist ( Ω ), roll ( ρ ), tilt ( τ ) and slide ( D y ). A statistical mechanical model was used to analyze the flexibility of the Escherichia coli genome. The replication terminus region displayed a low level of flexibility. A strong correlation can be seen between G+C content and flexibility. Average flexibilities in the coding regions were found to be significantly larger than those in non‐coding regions. The flexible characteristics in the 5′‐neighborhood of the coding regions and in three class sigma promoter sequences in the E. coli genome were also analyzed.