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HIV‐1 reverse transcriptase and integrase enzymes physically interact and inhibit each other
Author(s) -
Tasara Taurai,
Maga Giovanni,
Hottiger Michael O.,
Hübscher Ulrich
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02945-3
Subject(s) - integrase , reverse transcriptase , human immunodeficiency virus (hiv) , virology , enzyme , integrase inhibitor , chemistry , lentivirus , biology , biochemistry , antiretroviral therapy , rna , viral disease , viral load , gene
Ordered molecular interactions and structural changes must take place within the human immunodeficiency virus type 1 (HIV‐1) preintegration complex at various stages for successful viral replication. We demonstrate both physical and biochemical interactions between HIV‐1 reverse transcriptase and integrase enzymes. This interaction may have implications on the in vivo functions of the two enzymes within the HIV‐1 replication complex. It may be one of the various molecular interactions, which facilitate efficient HIV‐1 replication within the target cells.