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Down‐regulation of N ‐myristoyl transferase expression in human T‐cell line CEM by human immunodeficiency virus type‐1 infection
Author(s) -
Takamune Nobutoki,
Tanaka Tadahiro,
Takeuchi Hiroki,
Misumi Shogo,
Shoji Shozo
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02892-7
Subject(s) - virology , biology , human immunodeficiency virus (hiv) , cell culture , virus , transferase , viral replication , myristoylation , enzyme , genetics , biochemistry , phosphorylation
The present study focuses on the expression level of N ‐myristoyl transferase (NMT) in the course of human immunodeficiency virus type‐1 (HIV‐1) infection. HIV‐1 structural proteins were gradually expressed during the process of infection of the human T‐cell line CEM, whereas the expression levels of NMT subsequently decreased under the same conditions. In addition, the chronically HIV‐1‐infected T‐cell line CEM/LAV‐1 exhibited low expression levels of NMT. We hypothesize that the decrease in the expression level of NMT due to HIV‐1 infection may be related to the virus’ strategy that leads to its persistent replication.