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A plant Shaker‐like K + channel switches between two distinct gating modes resulting in either inward‐rectifying or ‘leak’ current
Author(s) -
Dreyer Ingo,
Michard Erwan,
Lacombe Benoı̂t,
Thibaud Jean-Baptiste
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02832-0
Subject(s) - gating , shaker , xenopus , potassium channel , chinese hamster ovary cell , chemistry , biophysics , channel (broadcasting) , leak , physics , biology , biochemistry , telecommunications , computer science , receptor , quantum mechanics , gene , vibration , thermodynamics
Among the Shaker‐like plant potassium channels, AKT2 is remarkable because it mediates both instantaneous ‘leak‐like’ and time‐dependent hyperpolarisation‐activated currents. This unique gating behaviour has been analysed in Xenopus oocytes and in COS and Chinese hamster ovary cells. Whole‐cell and single‐channel data show that (i) AKT2 channels display two distinct gating modes, (ii) the gating of a given AKT2 channel can change from one mode to the other and (iii) this conversion is under the control of post‐translational factor(s). This behaviour is strongly reminiscent of that of the KCNK2 channel, recently reported to be controlled by its phosphorylation state.