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Diva/Boo is a negative regulator of cell death in human glioma cells
Author(s) -
Naumann Ulrike,
Weit Simone,
Wischhusen Jörg,
Weller Michael
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02768-5
Subject(s) - regulator , diva , negative regulator , glioma , programmed cell death , microbiology and biotechnology , chemistry , biology , apoptosis , cancer research , virology , genetics , gene , signal transduction
Diva is a novel proapoptotic member of the Bcl‐2 protein family which binds apoptosis activating factor‐1 (APAF‐1). Diva is identical with Boo which was identified as a novel antiapoptotic Bcl‐2 family protein. Here, we report that Diva promotes the cell cycle exit of human glioma cells in response to serum deprivation and inhibits apoptosis of these cells induced by CD95 ligand or chemotherapeutic drugs. In glioma cells, Diva interferes with apoptotic signaling downstream of cytochrome c release, but upstream of caspase activation, consistent with an inhibitory effect on the mitochondrial amplification step involving the apoptosome and APAF‐1.