Premium
The Candida albicans Na + /H + antiporter exports potassium and rubidium
Author(s) -
Kinclová Olga,
Potier Serge,
Sychrová Hana
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02755-7
Subject(s) - rubidium , potassium , antiporters , alkali metal , chemistry , efflux , candida albicans , antiporter , saccharomyces cerevisiae , sodium , lithium (medication) , membrane transport , membrane , corpus albicans , isotopes of potassium , heterologous expression , biochemistry , yeast , biology , microbiology and biotechnology , recombinant dna , organic chemistry , gene , endocrinology
The Candida albicans Cnh1p belongs to the family of Na + /H + antiporters (TC 2.A.36) but it transports besides toxic sodium and lithium also rubidium and potassium. Upon heterologous expression in a Saccharomyces cerevisiae salt‐sensitive strain, the Cnh1p is targeted to the plasma membrane and its transport activity results in increased tolerance of cells to external alkali metal cations. The cation efflux activity of Cnh1p in S. cerevisiae depends on the gradient of protons across the plasma membrane, and a Cnh1p‐mediated K + efflux is involved in a cell response to sudden rise of cytoplasmic pH.