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The cAMP response element binding protein‐2 (CREB‐2) can interact with the C/EBP‐homologous protein (CHOP)
Author(s) -
Gachon Frédéric,
Gaudray Gilles,
Thébault Sabine,
Basbous Jihane,
Koffi Joseph Aman,
Devaux Christian,
Mesnard Jean-Michel
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02646-1
Subject(s) - creb , activating transcription factor , creb1 , transcription factor , leucine zipper , activator (genetics) , ccaat enhancer binding proteins , activating transcription factor 2 , enhancer , microbiology and biotechnology , repressor , bzip domain , response element , atf3 , biology , cyclic amp response element binding protein , creb binding protein , promoter , dna binding protein , gene , genetics , gene expression
cAMP response element binding protein‐2 (CREB‐2) is a basic leucine zipper (bZIP) factor that was originally described as a repressor of CRE‐dependent transcription but that can also act as a transcriptional activator. Moreover, CREB‐2 is able to function in association with the viral Tax protein as an activator of the human T‐cell leukemia virus type I (HTLV‐I) promoter. Here we show that CREB‐2 is able to interact with C/EBP‐homologous protein (CHOP), a bZIP transcription factor known to inhibit CAAT/enhancer‐dependent transcription. Cotransfection of CHOP with CREB‐2 results in decreased activation driven by the cellular CRE motif or the HTLV‐I proximal Tax‐responsive element, confirming that CREB‐2 and CHOP can interact with each other in vivo.