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Protein translocation machineries of peroxisomes
Author(s) -
Holroyd Claudia,
Erdmann Ralf
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02617-5
Subject(s) - peroxisome , peroxisomal targeting signal , cytosol , microbiology and biotechnology , transport protein , receptor , protein targeting , biology , biochemistry , chromosomal translocation , membrane protein , chemistry , membrane , enzyme , gene
Targeting of peroxisomal matrix and membrane proteins is performed by distinct transport machineries and requires the concerted action of at least 23 peroxins. Cargo recognition takes place in the cytosol and the multiple binding sites for peroxisomal signal sequence receptors at the peroxisomal membrane reflect the existence of an import cascade where the cargo‐loaded receptors successively interact with different components of the import machinery. These interactions are likely to trigger conformational changes of the proteins within the import cascade which are required for the consecutive steps of peroxisomal protein import: docking, translocation, cargo release and receptor recycling.