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The flavonoid baicalin inhibits superantigen‐induced inflammatory cytokines and chemokines
Author(s) -
Krakauer Teresa,
Li Bao Qun,
Young Howard A.
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02584-4
Subject(s) - superantigen , scutellaria baicalensis , baicalin , proinflammatory cytokine , chemokine , tumor necrosis factor alpha , macrophage inflammatory protein , monocyte , interleukin , peripheral blood mononuclear cell , cxcl2 , cytokine , immunology , biology , chemistry , microbiology and biotechnology , inflammation , t cell , medicine , immune system , biochemistry , in vitro , chemokine receptor , high performance liquid chromatography , traditional chinese medicine , alternative medicine , pathology , chromatography
Excessive release of proinflammatory cytokines mediates the toxic effect of superantigenic staphylococcal exotoxins (SE). Baicalin, a flavone isolated from the Chinese herb Scutellaria baicalensis Georgi and used in China to treat infectious diseases, inhibited SE‐stimulated T‐cell proliferation (by 98%) and production of interleukin 1β, interleukin 6, tumor necrosis factor, interferon γ, monocyte chemotactic protein 1, macrophage inflammatory protein (MIP)‐1α, and MIP‐1β mRNA and protein by human peripheral blood mononuclear cells. These data suggest that baicalin may be therapeutically useful for mitigating the pathogenic effects of SE by inhibiting the signaling pathways activated by superantigens.