Premium
Mathematical analysis of a mechanism for autonomous metabolic oscillations in continuous culture of Saccharomyces cerevisiae
Author(s) -
Wolf Jana,
Sohn Ho-Yong,
Heinrich Reinhart,
Kuriyama Hiroshi
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02562-5
Subject(s) - saccharomyces cerevisiae , mechanism (biology) , assimilation (phonology) , biological system , chemistry , biochemistry , biology , biophysics , biochemical engineering , physics , yeast , engineering , linguistics , philosophy , quantum mechanics
Autonomous metabolic oscillations were observed in aerobic continuous culture of Saccharomyces cerevisiae . Experimental investigation of the underlying mechanism revealed that several pathways and regulatory couplings are involved. Here a hypothetical mechanism including the sulfate assimilation pathway, ethanol degradation and respiration is transformed into a mathematical model. Simulations confirm the ability of the model to produce limit cycle oscillations which reproduce most of the characteristic features of the system.