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Helicobacter mustelae lipid A structure differs from that of Helicobacter pylori
Author(s) -
Thérisod Hélène,
Monteiro Mario A,
Perry Malcolm B,
Caroff Martine
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02496-6
Subject(s) - helicobacter pylori , lipid a , glucosamine , pathogen , chemistry , disaccharide , biochemistry , fatty acid , strain (injury) , bacteria , glycolipid , moiety , amide , stereochemistry , microbiology and biotechnology , biology , anatomy , genetics
The lipid A structure of the Gram‐negative bacterium Helicobacter mustelae , a ferret gastric pathogen responsible for the onset of gastric diseases in its host, was investigated. Two variant lipid A structures were found in the same strain. One structure contained a bisphosphorylated β‐(1→6)‐linked D ‐glucosamine backbone disaccharide with hydroxytetradecanoic acid in amide linkages. Unlike the structure described for the lipid A of the related human Helicobacter pylori gastric pathogen, which contains a C1 phosphate moiety, this lipid A presented phosphate groups at both the C1 and C4′ positions, and contained no octadecanoyl fatty acid, which is present in H. pylori . The second lipid A structure had a different fatty acid composition in that 3‐OH C 16 replaced most of the amide‐linked 3‐OH C 14 .