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Coordination between transcription and pre‐mRNA processing
Author(s) -
Cramer P.,
Srebrow A.,
Kadener S.,
Werbajh S.,
de la Mata M.,
Melen G.,
Nogués G.,
Kornblihtt A.R.
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02485-1
Subject(s) - rna polymerase ii , rna polymerase ii holoenzyme , transcription factor ii d , rna splicing , polyadenylation , general transcription factor , transcription (linguistics) , precursor mrna , microbiology and biotechnology , cleavage and polyadenylation specificity factor , transcription factor ii b , post transcriptional modification , polymerase , chemistry , biology , messenger rna , gene expression , rna , rna dependent rna polymerase , promoter , gene , genetics , linguistics , philosophy
A large body of work has proved that transcription by RNA polymerase II and pre‐mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy‐terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing.