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A role for Cajal bodies in assembly of the nuclear transcription machinery
Author(s) -
Gall Joseph G
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02461-9
Subject(s) - cajal body , rna polymerase ii , nucleolus , transcription (linguistics) , microbiology and biotechnology , rna polymerase iii , biology , rna polymerase i , transcription factories , organelle , polymerase , rna , chemistry , rna polymerase , genetics , nucleus , gene expression , gene , promoter , rna splicing , linguistics , philosophy
Cajal bodies (CBs) are small nuclear organelles that contain the three eukaryotic RNA polymerases and a variety of factors involved in transcription and processing of all types of RNA. A number of these factors, as well as subunits of polymerase (pol) II itself, are rapidly and specifically targeted to CBs when injected into the cell. It is suggested that pol I, pol II, and pol III transcription and processing complexes are preassembled in the CBs before transport to the sites of transcription on the chromosomes and in the nucleoli.