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Inhibition of cytokine‐induced vascular cell adhesion molecule‐1 expression; possible mechanism for anti‐atherogenic effect of Agastache rugosa
Author(s) -
Hong Jung-Joo,
Choi Jae-Hoon,
Oh Sei-Ryang,
Lee Hyeong-Kyu,
Park Jae-Hak,
Lee Kun-Yeong,
Kim Jung-Jae,
Jeong Tae-Sook,
Oh Goo Taeg
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02379-1
Subject(s) - cell adhesion molecule , vcam 1 , umbilical vein , microbiology and biotechnology , cell adhesion , cytokine , tumor necrosis factor alpha , chemistry , endothelial stem cell , biology , cell , biochemistry , immunology , icam 1 , in vitro
Adhesion molecules such as vascular cell adhesion molecule‐1 (VCAM‐1) play an important role during the early stages of atherogenesis. Agastache rugosa has an anti‐atherogenic effect in low density lipoprotein receptor −/− mice. Moreover, A. rugosa reduced macrophage infiltration and VCAM‐1 expression has been localized in aortic endothelium that overlies early foam cell lesions. This study ascertained that tilianin (100 μM), a major component of A. rugosa , inhibits the tumor necrotic factor‐α (TNF‐α)‐induced expression of VCAM‐1 by 74% in cultured human umbilical vein endothelial cells (HUVECs). Also, tilianin (100 μM) reduced TNF‐α‐induced activation of nuclear factor‐κB in HUVECs.