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The G protein β3 subunit 825T allele is a genetic marker for enhanced T cell response
Author(s) -
Lindemann Monika,
Virchow Sebastian,
Ramann Frank,
Barsegian Vahé,
Kreuzfelder Ernst,
Siffert Winfried,
Müller Norbert,
Grosse-Wilde Hans
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02339-0
Subject(s) - allele , immunocompetence , genotype , biology , protein subunit , immune system , t cell , antigen , microbiology and biotechnology , gene , immunology , genetics
The G protein β3 subunit ( GNB3 ) 825T allele is predictive of enhanced Gi protein activation. Studying the influence of C825T allele status on cellular in vitro immune responses towards recall antigens and interleukin‐2 stimulation we observed a 2–4‐fold, significantly increased proliferation in homozygous 825T (TT) vs. C825 allele (CC) carriers. Furthermore, lymphocyte chemotaxis and CD4 + T cell counts of individuals with TT+TC genotypes were significantly enhanced compared to the CC genotype. In summary, it appears that C825T allele status is highly predictive of immunocompetence and could be a candidate gene in disorders associated with inadequate immune response.