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Structural enzymology of biotin biosynthesis
Author(s) -
Schneider Gunter,
Lindqvist Ylva
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02325-0
Subject(s) - biotin , biochemistry , enzyme , biosynthesis , chemistry , computational biology , biotin deficiency , biology
Over the last years, significant progress has been made in the understanding of the genetics and enzymology of the biosynthetic pathway of the vitamin biotin. The enzymes catalyzing the last four steps of this pathway, from pimeloyl‐CoA to biotin, provide an ensemble of intriguing reaction mechanisms, which are presently being unravelled. The three‐dimensional structures for three of these enzymes are known and provide a framework to which on‐going mechanistic studies can be related.