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UV‐light‐dependent binding of a visual arrestin 1 isoform to photoreceptor membranes in a neuropteran ( Ascalaphus ) compound eye
Author(s) -
Bentrop Joachim,
Schillo Markus,
Gerdon Gabriele,
Draslar Kazimir,
Paulsen Reinhard
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02287-6
Subject(s) - arrestin , subfamily , biology , gene isoform , microbiology and biotechnology , rhodopsin , sensory system , visual phototransduction , g protein , receptor , signal transduction , g protein coupled receptor , gene , genetics , biochemistry , neuroscience , retinal
Arrestins are regulators of the active state of G‐protein‐coupled receptors. Towards elucidating the function of different arrestin subfamilies in sensory cells, we have isolated a novel arrestin 1, Am Arr1, from the UV photoreceptors of the neuropteran Ascalaphus macaronius . Am Arr1 forms a phylogenetic clade with antennal and visual Arr1 isoforms of invertebrates. Am Arr1 undergoes a light‐dependent binding cycle to photoreceptor membranes, as reported earlier only for members of the arrestin 2 subfamily. This suggests a common control mechanism for the active state of invertebrate rhodopsins and G‐protein‐coupled receptors of antennal sensory cells. Furthermore, it implies that a strict correlation of distinct arrestin isoforms to distinct functions is not a general principle for invertebrate sensory cells.