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Cross‐talk between IL‐6 and TGF‐β signaling in hepatoma cells
Author(s) -
Yamamoto Tetsuya,
Matsuda Tadashi,
Muraguchi Atsushi,
Miyazono Kohei,
Kawabata Masahiro
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02258-x
Subject(s) - transforming growth factor , microbiology and biotechnology , chemistry , signal transduction , biology
Interleukin‐6 (IL‐6) is a multifunctional cytokine that plays important roles in the immune system, hematopoiesis, and acute phase reactions. Transforming growth factor‐β (TGF‐β) also has pleiotropy including the production of acute phase proteins in hepatocytes. To elucidate the cross‐talk between IL‐6 and TGF‐β signaling pathways in hepatic cells, we investigated the effects of TGF‐β on IL‐6‐induced signal transducer and activator of transcription‐3 (STAT3) activation in a human hepatoma cell line, Hep3B. IL‐6‐induced activation of STAT3 activity and STAT3‐mediated gene expression were augmented by TGF‐β in Hep3B cells. We provide evidence that these activities were due to physical interactions between STAT3 and Sma‐ and MAD‐related protein‐3, bridged by p300. These results demonstrate a molecular mechanism of a cross‐talk between STAT3 and TGF‐β signaling pathways in hepatocytes.