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Mitochondria, aging and longevity – a new perspective
Author(s) -
Salvioli Stefano,
Bonafè Massimiliano,
Capri Miriam,
Monti Daniela,
Franceschi Claudio
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02199-8
Subject(s) - mitochondrion , longevity , microbiology and biotechnology , reactive oxygen species , biology , apoptosis , nucleus , perspective (graphical) , oxidative stress , biochemistry , genetics , computer science , artificial intelligence
A new perspective is emerging indicating that mitochondria play a critical role in aging not only because they are the major source and the most proximal target of reactive oxygen species, but also because they regulate stress response and apoptosis. Recent literature indicates that, in response to stress, a variety of molecules translocate to and localise in mitochondria. These molecules are likely to interact with each other, in order to mediate mitochondria/nucleus cross‐talk and to regulate apoptosis. We surmise that an integration of signals in multimolecular complexes occurs at mitochondrial level. These phenomena can be of critical importance for human aging and longevity.