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Pathophysiological relevance of mitochondria in NAD + metabolism
Author(s) -
Di Lisa Fabio,
Ziegler Mathias
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02198-6
Subject(s) - mitochondrion , nad+ kinase , organelle , metabolism , energy metabolism , microbiology and biotechnology , biochemistry , biology , nucleotide , chemistry , enzyme , endocrinology , gene
Pyridine nucleotides are mostly stored within mitochondria where they are involved in different functions ranging from energy metabolism to cellular signaling. Here we discuss the mechanisms of mitochondrial NAD + metabolism and release that may contribute to the crucial roles played by these organelles as triggers or amplifiers of physiological and pathological events.