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Homing markers for atherosclerosis: applications for drug delivery, gene delivery and vascular imaging
Author(s) -
Houston Parul,
Goodman Jo,
Lewis Alan,
Campbell Callum J,
Braddock Martin
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02191-3
Subject(s) - biopanning , ldl receptor , gene delivery , homing (biology) , drug delivery , in vivo , gene knockout , pathogenesis , phage display , cytokine , targeted drug delivery , knockout mouse , tumor necrosis factor alpha , peptide library , receptor , cancer research , biology , immunology , lipoprotein , drug , pharmacology , gene , genetic enhancement , peptide sequence , chemistry , cholesterol , antibody , endocrinology , biochemistry , genetics , ecology , organic chemistry
Endothelial dysfunction plays a major role in the pathogenesis of atherosclerosis. Pro‐inflammatory cytokines such as interleukin‐1β and tumour necrosis factor α activate endothelial cells changing their resting phenotype to become pro‐adhesive, pro‐thrombotic and pro‐atherogenic. Phage display in vivo biopanning has been used to identify peptide sequences that home to diseased regions of the vessel wall in low density lipoprotein receptor (LDLr) knockout mice. In LDLr knockout mice, peptide sequence determinants exhibiting organ specificity have been isolated. These sequences have applications for gene delivery, drug delivery and for improving contrast agents for vascular imaging.