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The adaptive regulation of amino acid transport system A is associated to changes in ATA2 expression
Author(s) -
Franchi Gazzola Renata,
Sala Roberto,
Bussolati Ovidio,
Visigalli Rossana,
Dall'Asta Valeria,
Ganapathy Vadivel,
Gazzola Gian C.
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02126-3
Subject(s) - chemistry , expression (computer science) , microbiology and biotechnology , biochemistry , biophysics , biology , computer science , programming language
The activity of transport system A for neutral amino acids is adaptively stimulated upon amino acid starvation. In cultured human fibroblasts this treatment causes an increase in the expression of the ATA2 system A transporter gene. ATA2 mRNA increase and transport stimulation are suppressed by system A substrates, but they are unaffected by other amino acids. Supplementation of amino acid‐starved cells with substrates of system A causes a decrease in both ATA2 mRNA and system A transport activity. These results suggest a direct relationship between ATA2 expression and system A transport activity.