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Growth factor‐dependent signaling and cell cycle progression
Author(s) -
Jones Steven M,
Kazlauskas Andrius
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02113-5
Subject(s) - cell cycle , cell cycle progression , microbiology and biotechnology , signal transduction , cell growth , growth factor , cell , biology , cell signaling , genetics , receptor
There are three central ideas contained within this review. Firstly, growth factor‐stimulated signaling is not restricted to a 30–60 min window, but occurs at a much later time as well. Secondly, the second wave of signaling overlaps temporally with the cell cycle program and may be directly responsible for engaging it. Thirdly, the G1 to S interval appears to encompass two distinct phases of the cell cycle, during which the coordinated activation of distinct sets of signaling enzymes drives cell cycle progression. Each of these concepts is likely to initiate new investigation and hence provide additional insight into the fundamental question of how growth factors drive cell proliferation.