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Unbalanced expression of VEGF and PEDF in ischemia‐induced retinal neovascularization
Author(s) -
Gao Guoquan,
Li Yan,
Zhang Dongchang,
Gee Stephen,
Crosson Craig,
Ma Jian-xing
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02110-x
Subject(s) - pedf , neovascularization , retinal , vascular endothelial growth factor , angiogenesis , vascular endothelial growth factor a , ischemia , endocrinology , chemistry , medicine , vegf receptors , ophthalmology
Retinal levels of vascular endothelial growth factor (VEGF) and pigment epithelium‐derived factor (PEDF), an angiogenic inhibitor, were measured and correlated with the ischemia‐induced retinal neovascularization in rats. The retinas with neovascularization showed a 5‐fold increase in VEGF while 2‐fold decrease in PEDF, compared to the age‐matched controls, resulting in an increased VEGF/PEDF ratio. The time course of the VEGF/PEDF ratio change correlated with the progression of retinal neovascularization. Changes in the VEGF and PEDF mRNAs preceded their protein level changes. These results suggest that an unbalance between angiogenic stimulators and inhibitors may contribute to retinal neovascularization.