Premium
Normal and cancer‐prone human cells respond differently to extremely low frequency magnetic fields
Author(s) -
Mangiacasale Rosamaria,
Tritarelli Alessandra,
Sciamanna Ilaria,
Can Maria,
Lavia Patrizia,
Barberis Massimo C.,
Lorenzini Rodolfo,
Cundari Enrico
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)02376-0
Subject(s) - fanconi anemia , apoptosis , biology , programmed cell death , genome instability , lymphoblast , cell , cancer research , cell culture , dna damage , microbiology and biotechnology , genetics , gene , dna , dna repair
Human lymphoblastoid cells of normal origin and from genetic instability syndromes, i.e. Fanconi anemia (FA) group C and ataxia telangectasia, were continuously exposed to extremely low frequency magnetic field (ELF‐MF). We report that ELF‐MF, though not perturbing cell cycle progression, increases the rate of cell death in normal cell lines. In contrast, cell death is not affected in cells from genetic instability syndromes; this reflects a specific failure of the apoptotic response. Reintroduction of complementation group C in FA cells re‐established the apoptotic response to ELF‐MF. Thus, genes implicated in genetic instability syndromes are relevant in modulating the response of cells to ELF‐MF.