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Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets
Author(s) -
Peters-Golden Marc,
Brock Thomas G
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)02374-7
Subject(s) - compartmentalization (fire protection) , intracellular , leukotriene , biosynthesis , microbiology and biotechnology , leukotriene c4 , chemistry , biology , biochemistry , enzyme , immunology , asthma
Leukotrienes are important lipid mediators implicated in the regulation of various cellular processes and in disease states as well as homeostasis. Regulation of leukotriene biosynthesis is therefore of considerable interest. Although the levels of expression and catalytic activity of leukotriene‐forming proteins have long been recognized as important determinants of leukotriene biosynthesis, it has recently become apparent that their intracellular compartmentalization also affects the integrated output of this biosynthetic pathway. In this minireview, we focus on the unexpected discovery that the nucleus is the key intracellular site for leukotriene biosynthesis and discuss the mechanisms that regulate protein localization and the potential implications of these findings.