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The possible involvement of CXCR4 in the inhibition of HIV‐1 infection mediated by DP178/gp41
Author(s) -
Xu Youg,
Zhang Xiaoyan,
Matsuoka Masao,
Hattori Toshio
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)02336-x
Subject(s) - gp41 , virus , virology , human immunodeficiency virus (hiv) , cxcr4 , biology , immunology , antigen , immune system , chemokine , epitope
The N‐ (N36/DP107) and C‐terminal peptides (C34/DP178) from two α‐helical domains of human immunodeficiency virus type 1 (HIV‐1) gp41 inhibited HIV infection. A single‐round infection using pseudotyped virus clarified that a greater amount of gp41‐derived peptides was necessary for the inhibition of R5 virus (ADA) infection than for that of X4 virus (LAI) infection. Furthermore, R5X4 virus (89.6) infection via CCR5 needs more peptides for inhibition than its infection via CXCR4 does. A high sensitivity of X4 virus was partially ascribed to the inhibition of the 12G5 binding to CXCR4 by DP178LAI.