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NADP‐malic enzyme from plants: a ubiquitous enzyme involved in different metabolic pathways
Author(s) -
Drincovich Marı́a F.,
Casati Paula,
Andreo Carlos S.
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)02331-0
Subject(s) - c4 photosynthesis , biochemistry , enzyme , oxidative decarboxylation , gene isoform , cytosol , chloroplast , biology , photosynthesis , malic enzyme , dehydrogenase , gene
NADP‐malic enzyme (NADP‐ME) is a widely distributed enzyme that catalyzes the oxidative decarboxylation of L ‐malate. Photosynthetic NADP‐MEs are found in C 4 bundle sheath chloroplasts and in the cytosol of CAM plants, while non‐photosynthetic NADP‐MEs are either plastidic or cytosolic in various plants. We propose a classification of plant NADP‐MEs based on their physiological function and localization and we describe recent advances in the characterization of each isoform. Based on the alignment of amino acid sequences of plant NADP‐MEs, we identify putative binding sites for the substrates and analyze the phylogenetic origin of each isoform, revealing several features of the molecular evolution of this ubiquitous enzyme.