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P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production
Author(s) -
Ferrari Davide,
Idzko Marco,
Dichmann Stefan,
Purlis Daniela,
Virchow Christian,
Norgauer Johannes,
Chiozzi Paola,
Di Virgilio Francesco,
Luttmann Werner
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)02306-1
Subject(s) - purinergic receptor , p2y receptor , extracellular , receptor , stimulation , intracellular , chemistry , microbiology and biotechnology , nucleotide , biochemistry , biology , endocrinology , gene
Extracellular nucleotides elicit multiple responses in eosinophils but no information on expression of purinergic receptors in these cells is available so far. In the present study we show that human eosinophils express the following P2Y and P2X subtypes: P2Y 1 , P2Y 2 , P2Y 4 , P2Y 6 , P2Y 11 , and P2X 1 , P2X 4 , P2X 7 , whose stimulation results in intracellular Ca 2+ increase and production of large amounts of reactive oxygen intermediates. These events are stimulated or inhibited, respectively, by P2 receptor agonists or antagonists.