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NADPH oxidase activity is required for endothelial cell proliferation and migration
Author(s) -
Abid Md.Ruhul,
Kachra Zarin,
Spokes Katherine C.,
Aird William C.
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)02305-x
Subject(s) - nadph oxidase , angiogenesis , xanthine oxidase , oxidase test , endothelial stem cell , chemistry , microbiology and biotechnology , cell growth , biochemistry , enzyme , biology , cancer research , in vitro
NADPH oxidase has been shown to play an important role in cardiovascular biology. The goal of the present study was to determine whether NADPH oxidase activity is important for endothelial cell growth and migration. In proliferation assays, growth factor‐ or serum‐induced DNA synthesis in three different types of human endothelial cells was abrogated by inhibitors of NADPH oxidase, but not by inhibitors of xanthine oxidase or nitric oxide synthase. Moreover, vascular endothelial growth factor‐induced migration of human endothelial cells was suppressed in the presence of NADPH oxidase inhibitors. These results support a potential role for NADPH oxidase in mediating angiogenesis.