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The T cell antigen receptor activates phosphatidylinositol 3‐kinase‐regulated serine kinases protein kinase B and ribosomal S6 kinase 1
Author(s) -
Lafont Virginie,
Astoul Emmanuelle,
Laurence Arian,
Liautard Janny,
Cantrell Doreen
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)02235-3
Subject(s) - p70 s6 kinase 1 , map kinase kinase kinase , map2k7 , ask1 , mitogen activated protein kinase kinase , cyclin dependent kinase 9 , cyclin dependent kinase 2 , ribosomal s6 kinase , ribosomal protein s6 , kinase , microbiology and biotechnology , akt2 , c raf , cyclin dependent kinase 4 , biology , chemistry , akt1 , protein kinase a , phosphorylation , protein kinase b
The present study has explored T cell antigen receptor‐regulated serine kinases in human T cells. The results identify two phosphatidylinositol 3‐kinase (PI3K)‐controlled serine kinases operating downstream of the T cell receptor (TCR) in primary T cells: (i) protein kinase B whose activation regulates the phosphorylation of glycogen synthase kinase 3 and (ii) ribosomal S6 kinase 1, a kinase with a critical role in the regulation of protein synthesis and cell growth. T cells express two isoforms of S6k1: a 70 kDa cytoplasmic kinase and an 85 kDa isoform that has a classic nuclear localisation. TCR ligation triggers a parallel engagement of both the 70 and 85 kDa isoforms of S6k1 in a response that requires PI3K function.