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A CDE/CHR tandem element regulates cell cycle‐dependent repression of cyclin B2 transcription
Author(s) -
Lange-zu Dohna Christine,
Brandeis Michael,
Berr Frieder,
Mössner Joachim,
Engeland Kurt
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)02133-5
Subject(s) - cyclin a , cell cycle , cyclin b , cyclin dependent kinase 1 , cyclin b1 , cyclin a2 , transcription (linguistics) , microbiology and biotechnology , cyclin d , cyclin e , cyclin , biology , cell , genetics , linguistics , philosophy
Cyclin B is an important regulator of progression through the cell division cycle. The oscillating appearance of cyclin B1 and B2 proteins during the cell cycle is in part due to fluctuating mRNA levels. We had identified earlier a tandem promoter element named cell cycle‐dependent element (CDE) and cell cycle genes homology region (CHR) which regulates cell cycle‐dependent transcription of cdc25C , cyclin A and cdc2 . Here we describe that cyclin B2 transcription is repressed through a novel CDE/CHR element in resting and G 1 cells. By relief of this repression in S and G 2 oscillating expression of cyclin B2 mRNA is achieved during the cell cycle.