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Molecular identification of a glucose transporter from fish muscle 1
Author(s) -
Planas Josep V.,
Capilla Encarnación,
Gutiérrez Joaquim
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)02020-2
Subject(s) - glucose transporter , glut1 , glut4 , gene isoform , skeletal muscle , biology , transporter , homology (biology) , fish <actinopterygii> , glucose uptake , cloning (programming) , glucose transporter type 1 , biochemistry , microbiology and biotechnology , gene , endocrinology , insulin , fishery , computer science , programming language
In mammals and birds, several isoforms of facilitative glucose transporters have been identified (GLUT1–4), but no information is available regarding the molecules involved in glucose transport in other vertebrates. Here we report the cloning of a GLUT molecule from fish muscle with high sequence homology to GLUT4 and containing features characteristic of a functional GLUT. Fish GLUT is expressed predominantly in skeletal muscle, kidney and gill, which are tissues with known high glucose utilization. These results indicate that fish GLUT is structurally, and perhaps functionally, similar to the other known GLUTs expressed in muscle in mammalian and avian species.