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AMP‐activated protein kinase counteracted the inhibitory effect of glucose on the phosphoenolpyruvate carboxykinase gene expression in rat hepatocytes
Author(s) -
Hubert Aurélie,
Husson Annie,
Chédeville Arlette,
Lavoinne Alain
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)02006-8
Subject(s) - phosphoenolpyruvate carboxykinase , ampk , protein kinase a , amp activated protein kinase , gene expression , chemistry , gluconeogenesis , gene , inhibitory postsynaptic potential , transcription (linguistics) , pyruvate kinase , kinase , biochemistry , biology , microbiology and biotechnology , endocrinology , enzyme , glycolysis , linguistics , philosophy
The effect of AMP‐activated protein kinase (AMPK) in the regulation of the phosphoenolpyruvate carboxykinase (PEPCK) gene expression was studied in isolated rat hepatocytes. Activation of AMPK by AICAR counteracted the inhibitory effect of glucose on the PEPCK gene expression, both at the mRNA and the transcriptional levels. It is proposed that a target for AMPK is involved in the inhibitory effect of glucose on PEPCK gene transcription.