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Expression of Mona (monocytic adapter) in myeloid progenitor cells results in increased and prolonged MAP kinase activation upon macrophage colony‐stimulating factor stimulation
Author(s) -
Bourgin Caroline,
Bourette Roland,
Mouchiroud Guy,
Arnaud Sylvie
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01906-2
Subject(s) - grb2 , mapk/erk pathway , macrophage colony stimulating factor , microbiology and biotechnology , signal transducing adaptor protein , tyrosine kinase , myeloid , signal transduction , stimulation , kinase , phosphorylation , biology , chemistry , cancer research , macrophage , endocrinology , biochemistry , in vitro
Mona is an SH3 and SH2 domain‐containing adapter molecule that is induced during monocytic differentiation. Here we have first shown that M‐CSFR is the major Mona partner in M‐CSF signaling, the interaction being mediated through tyrosine 697 of the receptor. Next we asked whether Mona expression would alter the Ras/MAP kinase pathway since Mona is a likely competitor of Grb2 for binding to M‐CSFR. We found that M‐CSF induced late and massive phosphorylation of ERK molecules in Mona‐expressing myeloid cells compared to non‐expressing cells. These results suggest that Mona expression might modify M‐CSF signaling during monocytic differentiation.