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The initial pathogenesis of cadmium induced renal toxicity
Author(s) -
Griffin Julian L.,
Walker Lee A.,
Troke Jeff,
Osborn Dan,
Shore Richard F.,
Nicholson Jeremy K.
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01843-3
Subject(s) - pathogenesis , toxicity , cadmium , medicine , chemistry , pharmacology , organic chemistry
The novel application of magic angle spinning 1 H NMR spectroscopy, coupled with pattern recognition techniques, has identified biochemical changes in lipid and glutamate metabolism that precede classical nephrotoxicity. These changes occurred in the bank vole ( Clethrionomys glareolus ) after chronic dosing, at a low level of exposure and at a renal Cd 2+ concentration (8.4 μg/g dry wt) that was nearly two orders of magnitude below the WHO critical organ concentration (200 μg/g wet wt). These early stage effects of Cd 2+ on the biochemistry of renal tissue may reflect adaptation mechanisms to the toxic insult or the preliminary stages of the toxicological cascade.