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The gene for hepatocyte nuclear factor (HNF)‐4α is activated by glucocorticoids and glucagon, and repressed by insulin in rat liver
Author(s) -
Oyadomari Seiichi,
Matsuno Fumihiko,
Chowdhury Shoaib,
Kimura Tatsuya,
Iwase Katsuro,
Araki Eiichi,
Shichiri Motoaki,
Mori Masataka,
Takiguchi Masaki
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01840-8
Subject(s) - endocrinology , medicine , glucagon , hepatocyte nuclear factors , insulin , hepatocyte , hepatocyte nuclear factor 4 , hormone , streptozotocin , chemistry , transcription factor , biology , diabetes mellitus , gene , nuclear receptor , biochemistry , in vitro
The gene for a transcription factor hepatocyte nuclear factor‐4α (HNF‐4α) is responsible for maturity‐onset diabetes of the young, type 1. We examined hormonal regulation of the HNF‐4α gene in the liver. Stimulation of primary‐cultured rat hepatocytes with dexamethasone or glucagon led to induction of HNF‐4α mRNA, being antagonized by insulin. In the liver of streptozotocin‐induced diabetic rat, mRNA and protein levels for HNF‐4α were elevated, and were normalized by insulin treatment. Therefore, HNF‐4α in the liver is likely to be involved in the regulation of glucose metabolism in response to these hormones.