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Characterization of the chitin biosynthesis process as a compensatory mechanism in the fks1 mutant of Saccharomyces cerevisiae
Author(s) -
Garcı́a-Rodriguez L.J,
Trilla J.A,
Castro C,
Valdivieso M.H,
Durán A,
Roncero C
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01835-4
Subject(s) - chitin , saccharomyces cerevisiae , mutant , biosynthesis , biochemistry , chitin synthase , chemistry , intracellular , mechanism (biology) , gene , chitosan , philosophy , epistemology
Deletion of the 1,3‐β‐ D ‐glucan synthase gene FKS1 in Saccharomyces cerevisiae induces a compensatory mechanism that is reflected in a significant increase in chitin synthase III (CSIII) activity, leading to high rates of chitin synthesis. Deregulation of CSIII activity is mainly due to the intracellular delocalization of Chs3p and Chs4p, the two main components of the CSIII active complex.