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M‐ABC2, a new human mitochondrial ATP‐binding cassette membrane protein
Author(s) -
Zhang Fang,
Hogue Douglas L.,
Liu Lin,
Fisher Cynthia L.,
Hui David,
Childs Sarah,
Ling Victor
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01823-8
Subject(s) - pseudogene , gene , microbiology and biotechnology , mitochondrion , biology , mitochondrial dna , complementary dna , inner mitochondrial membrane , hspa9 , genetics , peptide sequence , genome
We have isolated a human cDNA encoding a novel ATP‐binding cassette (ABC) protein whose gene was previously localized to chromosome 1q42 [Allikmets et al. (1995) Mamm. Genome 6, 111–117]. The gene transcript is expressed in all human tissues examined, with the highest levels in bone marrow. A non‐expressed pseudogene also exists at chromosome 15q13–14. The new protein, which is most similar to the mitochondrial (M)‐ABC1 protein, was also localized to mitochondria and therefore designated ‘M‐ABC2’. The N‐terminus of M‐ABC2 was shown to contain a mitochondrial‐targeting signal sequence.