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Cloning and characterization of human histone deacetylase 8
Author(s) -
Van den Wyngaert Ilse,
de Vries Winfred,
Kremer Andreas,
Neefs Jean-Marc,
Verhasselt Peter,
Luyten Walter H.M.L.,
Kass Stefan U.
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01813-5
Subject(s) - hdac8 , biology , histone deacetylase 2 , genetics , sap30 , histone deacetylase , hdac11 , microbiology and biotechnology , histone , gene
To date, seven different human histone deacetylases (HDACs) have been identified, which fall into two distinct classes. We have isolated and characterized a cDNA encoding a novel human HDAC, which we name HDAC8. HDAC8 shows a high degree of sequence similarity to HDAC1 and HDAC2 and thus belongs to the class I of HDACs. HDAC8 is expressed in a variety of tissues. Human cells overexpressing HDAC8 localize the protein in sub‐nuclear compartments whereas HDAC1 shows an even nuclear distribution. In addition, the HDAC8 gene is localized on the X chromosome at position q13, which is close to the XIST gene and chromosomal breakpoints associated with preleukemia.