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Gene expression profiling: monitoring transcription and translation products using DNA microarrays and proteomics
Author(s) -
Celis Julio E,
Kruhøffer Mogens,
Gromova Irina,
Frederiksen Casper,
Østergaard Morten,
Thykjaer Thomas,
Gromov Pavel,
Yu Jinsheng,
Pálsdóttir Hildur,
Magnusson Nils,
Ørntoft Torben F
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01771-3
Subject(s) - dna microarray , proteomics , computational biology , biology , gene expression profiling , gene expression , gene , dna , bioinformatics , genetics
Novel and powerful technologies such as DNA microarrays and proteomics have made possible the analysis of the expression levels of multiple genes simultaneously both in health and disease. In combination, these technologies promise to revolutionize biology, in particular in the area of molecular medicine as they are expected to reveal gene regulation events involved in disease progression as well as to pinpoint potential targets for drug discovery and diagnostics. Here, we review the current status of these technologies and highlight some studies in which they have been applied in concert to the analysis of biopsy specimens.