Premium
STAM2, a new member of the STAM family, binding to the Janus kinases
Author(s) -
Endo Kazuhiro,
Takeshita Toshikazu,
Kasai Hirotake,
Sasaki Yoshiteru,
Tanaka Nobuyuki,
Asao Hironobu,
Kikuchi Kazu,
Yamada Mitsuhiro,
Chen Min,
O'Shea John J.,
Sugamura Kazuo
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01760-9
Subject(s) - janus kinase , kinase , microbiology and biotechnology , mutant , janus kinase 2 , signal transduction , chemistry , sh3 domain , dna , dna synthesis , complementary dna , stimulation , biology , gene , receptor tyrosine kinase , biochemistry , endocrinology
We here cloned a cDNA encoding STAM2, a new member of the STAM family, which contains an SH3 domain and ITAM. STAM2 like STAM1 is associated with Jak2 and Jak3, and involved in the signaling for DNA synthesis and c‐ myc induction mediated by IL‐2 and GM‐CSF. Co‐expression of the SH3 deletion mutants of STAM1 and STAM2 induces an additive effect on suppressing DNA synthesis upon stimulation with IL‐2 and GM‐CSF, suggesting that STAM1 and STAM2 exhibit compensatory effects on the signaling pathways downstream of Jak2 and Jak3 upon stimulation with GM‐SCF and IL‐2, respectively.