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The role of protein structure in genomics
Author(s) -
Domingues Francisco S.,
Koppensteiner Walter A.,
Sippl Manfred J.
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01678-1
Subject(s) - structural genomics , genomics , computational biology , exploit , function (biology) , functional genomics , protein structure , protein function prediction , genome , protein function , sequence (biology) , computer science , gene , biology , genetics , biochemistry , computer security
The genome projects produce an enormous amount of sequence data that needs to be annotated in terms of molecular structure and biological function. These tasks have triggered additional initiatives like structural genomics. The intention is to determine as many protein structures as possible, in the most efficient way, and to exploit the solved structures for the assignment of biological function to hypothetical proteins. We discuss the impact of these developments on protein classification, gene function prediction, and protein structure prediction.