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Tau aggregation into fibrillar polymers: taupathies
Author(s) -
Avila Jesús
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01676-8
Subject(s) - hyperphosphorylation , tau protein , microtubule , degeneration (medical) , neuroscience , chemistry , biophysics , biology , microbiology and biotechnology , medicine , biochemistry , alzheimer's disease , pathology , disease , phosphorylation
Different neurological disorders, known as taupathies have been recently described. In these disorders it has been suggested that modifications in the microtubule‐associated protein tau could cause neural degeneration in specific regions. Although these regions are different in the different taupathies, some common features appear to occur in all of them: abnormal hyperphosphorylation of tau and aberrant tau aggregation. These two features are commented upon in this review.