Premium
Ligand–protein interactions in nuclear receptors of hormones
Author(s) -
Egea Pascal F,
Klaholz Bruno P,
Moras Dino
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01672-0
Subject(s) - nuclear receptor , pelp 1 , receptor , chemistry , hormone , microbiology and biotechnology , nuclear receptor coactivator 1 , transcription factor , biophysics , biochemistry , nuclear protein , hormone receptor , biology , genetics , gene , cancer , breast cancer
Nuclear hormone receptors are transcription factors regulated by lipophilic ligands. These hormones bind to their nuclear receptor targets using an induced fit mechanism that triggers a large conformational change and generates the proper surface for the binding of protein coactivators. The molecular details of the various steps of this activation process or its inhibition by antagonists are now understood for several nuclear receptors.