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Sphingosine‐1‐phosphate: signaling inside and out
Author(s) -
Spiegel Sarah,
Milstien Sheldon
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01670-7
Subject(s) - ceramide , lipid signaling , sphingosine , sphingolipid , microbiology and biotechnology , second messenger system , sphingosine 1 phosphate , signal transduction , intracellular , receptor , mediator , biology , cell signaling , g protein coupled receptor , chemistry , biochemistry , apoptosis
Ample evidence indicates that sphingosine‐1‐phosphate (SPP) can serve as an intracellular second messenger regulating calcium mobilization, and cell growth and survival. Moreover, the dynamic balance between levels of the sphingolipid metabolites, ceramide and SPP, and consequent regulation of opposing signaling pathways, is an important factor that determines whether a cell survives or dies. SPP has recently also been shown to be the ligand for the EDG‐1 family of G‐protein‐coupled receptors, which now includes EDG‐1, ‐3, ‐5, ‐6 and ‐8. SPP is thus a lipid mediator that has novel dual actions signaling inside and outside of the cell.