Premium
Redox‐dependent signal transduction
Author(s) -
Finkel Toren
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01669-0
Subject(s) - reactive oxygen species , signal transduction , microbiology and biotechnology , superoxide , intracellular , hydrogen peroxide , redox , chemistry , stimulation , biochemistry , second messenger system , biophysics , biology , enzyme , neuroscience , organic chemistry
Reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide appear to be transiently produced in response to growth factor and cytokine stimulation. A variety of evidence suggests that this ligand‐stimulated change in the cellular redox state participates in downstream signal transduction. This review will focus on the effects of ROS on signal transduction pathways, the molecules that regulate intracellular ROS production and the potential protein targets of oxidants.