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Fugu: a compact vertebrate reference genome
Author(s) -
Venkatesh Byrappa,
Gilligan Patrick,
Brenner Sydney
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01659-8
Subject(s) - genome , vertebrate , biology , fugu , genetics , gene , intergenic region , human genome , takifugu rubripes , computational biology , evolutionary biology
At 400 Mb, the Japanese pufferfish, Fugu rubripes , has the smallest vertebrate genome but has a similar gene repertoire to other vertebrates. Its genes are densely packed with short intergenic and intronic sequences devoid of repetitive elements. It likely has a mutational bias towards DNA elimination and is probably close to a ‘minimal’ vertebrate genome. As such it is a useful reference genome for gene discovery and gene validation in other vertebrates. Its usefulness in the discovery of conserved regulatory elements has already been demonstrated. The Fugu genome sequence is a good complement to genetic studies in other vertebrates.