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Absorption and metabolism of genistin in the isolated rat small intestine
Author(s) -
Andlauer Wilfried,
Kolb Jochen,
Fürst Peter
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01642-2
Subject(s) - genistin , genistein , metabolite , chemistry , metabolism , absorption (acoustics) , small intestine , in vivo , pharmacology , endocrinology , biochemistry , biology , materials science , daidzein , microbiology and biotechnology , composite material
Uptake and intestinal metabolism of physiologically active genistin were studied in an ex vivo intestinal perfusion model; luminally applied concentrations were 5.9, 12.0, and 23.8 μmol/l. The intestinal absorption of genistin was 14.9% (±2.3, n =9), irrespective of the amounts applied. The majority of the absorbed genistin appeared as genistein glucuronide (11.6%), also recovered as the main metabolite on the luminal side (19.5%). Minor amounts of genistin (1.3%) and genistein (1.9%) were found on the vascular side, whereas 15.4% of applied genistin was luminally cleaved to yield genistein. Sulfate derivatives of genistein or genistin were not observed.