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A novel gene derived from developing spinal cords, SCDGF , is a unique member of the PDGF/VEGF family
Author(s) -
Hamada Tsuyoshi,
Ui-Tei Kumiko,
Miyata Yuhei
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01640-9
Subject(s) - platelet derived growth factor receptor , spinal cord , microbiology and biotechnology , growth factor , biology , gene , vascular endothelial growth factor , in vitro , embryonic stem cell , vascular endothelial growth factor b , platelet derived growth factor , vascular endothelial growth factor a , vegf receptors , cancer research , receptor , genetics , neuroscience
We isolated a novel gene designated spinal cord‐derived growth factor ( SCDGF ). Its expression was increased in chick spinal cords with embryonic development and decreased after hatching. The amino acid sequences of chick and human SCDGFs revealed a putative signal sequence followed by a CUB domain and a region homologous to the members of the platelet‐derived growth factor/vascular endothelial growth factor family. Furthermore, human SCDGF secreted from the cells showed a mitogenic activity for 10T1/2 cells in vitro. These results led us to speculate that SCDGF plays an important role in the development of the spinal cord.